I'm sure a purist (or someone that fits central heating for a living) would argue something about convection of the heat, but I'd have thought you'd be OK. The valve actuator just "turns on" and "off" the flow through the rad. I'd assume it doesn't really matter which end cuts of the flow, surely the same affect will be had (value to off = flow stops, hot water doesn't enter the rad etc).
Probably more importantly would be to check the valve body (ie the wet bit that Idratek dont supply) as these are often, but not always, designed to be 1-way. I assume this has to do with the way the valve is gated. If you're putting the actuators on an existing system then "of course"the bodies will already be the right way around (or bidirectional).
I'm sure someone that does this for a living will be along with a definitive answer, but meantime hope this helps.