Usually you would have a main flow and return pipe going out from the boiler. Radiators would then be teed off those pipes, so each radiator has it's own connection to the flow and return. Most TRVs are a drop in replacement for the existing connection valve, although some pipework alteration may be required to fit them in some circumstances.
The new range of LightwaveRF heating controls are due to be released in March and they do look OK on paper. Historically LightwaveRF equipment has been "one-way" communication and the new controls will be their first attempt at "two-way" communication, so it will be interesting to see how they stack up against alternative systems like Z-Wave, HeatGenius, EvoHome, ELV/FS20 etc.
Unfortunately there's also been a significant price rise on LightwaveRF equipment at the beginning of the year, previously one of their strengths was their value - but now they're pitched at a similar price point to technologies that IMHO have better features and that are technically more advanced.
I've not used Domoticz myself, but have heard good things about it. I've used RFXCom equipment for many years now and it's been one of my most successful purchases to date. I started with separate USB receivers and moved up to the LAN enclosure with 868MHz receiver and 433 receiver / transmitter modules. I've got two of those beasts and they're great :-) I've not tried the newer RFXtrx433 yet, but plan to add one to my set-up soon!
For what it's worth, I've been slowly migrating 14 odd years worth of various HA equipment over to Z-Wave during the past 3 years as funds permit. Z-Wave has been awesome for me so far - coming from X10 / HomeEasy / Byron equipment with their one-way fire-and-hope transmissions to a system that guarantees that when I shut the garage door everything has been turned off, has been a much welcomed change!
Hope that helps!