Issue is with FTDI chips generating too many interrupts that can cause the Pi to hit NAK throttle threshold. Easily solved with the following
Add, dwc_otg.nak_holdoff=1 to /boot/cmdline.txt which gives you upto ~3MBaud so probably fine for most cases.
Add, dwc_otg.nak_holdoff=1 to /boot/cmdline.txt which gives you upto ~3MBaud so probably fine for most cases.
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