Hi David,
I can recommend the Honeywell Evohome system with its HR92 radiator controllers and boiler control. However, this system is proprietary, but it is possible to integrate it into the home automation software Domoticz. It uses a proprietary 868MHz protocol to communicate. The HR92 radiator controllers only have one motor which controls the valve and there's an LCD display showing current setpoint or temperature. Local control is all handled via a rotating control on the top of the device which is similar to some manual TRVs, but has an additional confirmation button below the rotating control, just above the LCD display (the LCD display is hinged and can flip out). There are no audible confirmations on the HR92 device. The system also has a central touchscreen controller, but this also doesn't have any audio accessibility features as far as I'm aware. I can't comment much further on the system's accessibility, except to say there are Honeywell Android/IOS apps and more recently limited control via any browser has also been added and all these will offer some form of spoken feedback.
Let me know if you need any more info and I'm sure others can also provide more details on the Honeywell system.
Dan