I can answer this because I have done a lot of research into this configuration. I actually have a 438, so same boiler too.
In order to have two flow temperatures for CH and HW, you need to use the ebus wiring centre, an ebus thermostat and then also the HW cylinder sensors etc. Unfortunately its an all or nothing.
The other thing that took me by surprise is that the VR33 has a lower hierarchy priority to the ebus room stat, so is completely ignored. So you cannot have OT managing the variable target flow any more.
Evohome via OT also operates as a single flow system but can atleast determine if it needs to be full or modulates. I can go on forever on this. But you need to make a choice. Its either all Evohome or all Vaillant controls.